ω-3,毒药癌症肿瘤

Omega-3毒药毒药

3D tumors that disintegrate within a few days thanks to the action of a well-known Omega-3 (DHA, found mainly in fish) — this is the exceptional discovery by University of Louvain. Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die. Credit: Copyright UCLouvain

所谓的“好脂肪酸”对于人类健康至关重要,并追求那些试图健康吃的人。在ω-3脂肪酸中,DHA或二十二碳六烯酸对脑功能,视觉和炎症现象的调节至关重要。

除了这些美德,DHA还与癌症发生率的降低有关。它如何运作是Louvain大学的多学科团队(Uclouvain)研究人员的主要发现主题,他刚才阐明了允许DHA和其他相关脂肪酸的生化机制来减缓肿瘤的发育。这是最近在着名期刊上发表的主要进展细胞新陈代谢

Key to the discovery: interdisciplinarity

In 2016, Olivier Feron’s UCLouvain team, which specializes in oncology, discovered that cells in an acidic microenvironment (acidosis) within tumors replace glucose with lipids as an energy source in order to multiply. In collaboration with UCLouvain’s Cyril Corbet, Prof. Feron demonstrated in 2020 that these same cells are the most aggressive and acquire the ability to leave the original tumor to generate metastases. Meanwhile, Yvan Larondelle, a professor in the UCLouvain Faculty of Bioengineering, whose team is developing improved dietary lipid sources, proposed to Prof. Feron that they combine their skills in a research project, led by PhD candidate Emeline Dierge, to evaluate the behavior of tumor cells in the presence of different fatty acids.


3D tumors that disintegrate within a few days thanks to the action of a well-known Omega-3 (DHA, found mainly in fish) — this is the exceptional discovery by University of Louvain. Hungry for fatty acids, tumor cells in acidosis gorge themselves on DHA but are unable to store it correctly and literally poison themselves. The result? They die. Credit: Copyright UCLouvain

由于支持Louvain,比利时癌症基金会和TélévieTelethon的支持,该团队迅速发现这些酸性肿瘤细胞根据它们吸收的脂肪酸径向相反的方式反应。在几周之内,结果令人印象深刻和令人惊讶。“我们很快发现某些脂肪酸刺激了肿瘤细胞,而其他脂肪酸则杀死它们,”研究人员解释说。DHA字面上诋毁他们。

A fatal overload

毒药通过称为硬质裂化的现象,一种与某些脂肪酸的过氧化有关的细胞死亡的现象。细胞中不饱和脂肪酸的量越大,它们氧化的风险越大。通常,在肿瘤内的酸性隔室中,细胞在脂质液滴中储存这些脂肪酸,一种束脂肪酸免受氧化的束。但在大量DHA存在下,肿瘤细胞被淹没并不能储存DHA,氧化并导致细胞死亡。通过使用防止脂液滴形成的脂质代谢抑制剂,研究人员能够观察到这种现象进一步扩增,这证实了所识别的机制并打开了组合治疗可能性的门。

对于他们的研究,Uclouvain研究人员使用了3D肿瘤细胞培养系统,称为球状体。在DHA的存在下,球形首先生长然后爆发。该团队还将富含DHA的饮食给予肿瘤的小鼠。结果:与常规饮食中的小鼠相比,肿瘤发育显着减缓。

这个Uclouvain的研究表明DHA在战斗癌症中的价值。“对于成年人来说,”Uclouvain研究人员表示,“建议每天至少消耗250毫克DHA。但研究表明,我们的饮食平均每天提供50至100毫克。这远低于最低推荐的摄入量。“

参考:2021年6月11日,细胞新陈代谢
DOI: 10.1016/j.cmet.2021.05.016

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