科学家成功映射Telomerase,发现各种癌症风险

Telomerase地图

调聚物映射可能提高我们对癌症及其处理的知识,StigE表示博杰森信用大学哥本哈根分校

研究者首次成功绘制调聚物图,发现调聚物基因差异与各种癌症风险和调聚物长度相关联。

协同国际研究队哥本哈根大学研究者首次绘制调聚物图 一种对正常细胞老化 产生恢复效果的酶发现刚发布自然遗传学并向前跨步 抗癌

绘制青春细胞喷泉-调聚物由全球1,000多位研究人员参与的重大研究项目、四年辛勤工作、欧盟5500万丹麦克朗和20万多人血样等结果这是有史以来最大协作项目 进行癌症遗传学

斯蒂格Eyabovip2021Bojesen是哥本哈根大学卫生医学系的研究员和赫列夫大学医院临床生物化学系的教职专家,他带头绘制调聚物-一种能为细胞染色体创造新端点的酶-即所谓的调聚物-换句话说 青春之手机

并伴有各种癌症风险 和数位数长度出人意料的发现是,引起疾病的变异与改变调聚物长度的变异不同。表示调聚物比先前假设要复杂得多,博杰森

yabo124调聚物映射是一项重要发现,因为调聚物是细胞生物中最基本酶之一延长调频器长度,使其与启动分机前的长度相同

Tromere系统映射可能提高我们对癌症及其处理的知识,并随着新发现,癌症和Tromere长度之间的遗传关系首次得到彻底描述, Stig E表示 。博杰森

Telomeres手机多路票

人体由5千万万或5万亿细胞组成,每个细胞有46染色体,即核中含有我们遗传素材的结构脱氧核糖核酸.染色体尾部受所谓的调频器保护调聚物作用保护染色体 方式与鞋带尾端的塑料链基本相同每当细胞分治时 调聚物会变短一点 最终会变短到无法保护染色体

广度说来,每个细胞都多车票, 每当细胞分治时, 色素端数将用完一程离散后 细胞再分不开 并自然会退休体内某些特殊细胞可激活调聚物,它可再次延长调聚物

性细胞或其他干细胞必须能够除法多于正常细胞,并有此特征不幸的是,癌症细胞发现把戏,已知它们还产生调聚物并因此人工保持青春yabo124调聚变基因因此在癌症生物学中起着重要作用, 研究者正是通过识别癌症基因来想象你可提高识别率和处理率

基因像国地图绘制时可以看到各城市正在发生的事情Telomerase Land中市之一决定是发展乳癌还是卵巢癌,而基因的其他部分则决定调聚物长度。映射调聚器向预测开发不同癌症风险迈出重要一步简言之,我们的发现非常出人意料并指向多方向与所有良好研究一样, 我们的工作提供许多答案,博杰森

参考:多独立变量TERT测试locus are associated with telomere length and risks of breast and ovarian cancer" by Stig E Bojesen, Karen A Pooley, Sharon E Johnatty, Jonathan Beesley, Kyriaki Michailidou, Jonathan P Tyrer, Stacey L Edwards, Hilda A Pickett, Howard C Shen, Chanel E Smart, Kristine M Hillman, Phuong L Mai, Kate Lawrenson, Michael D Stutz, Yi Lu, Rod Karevan, Nicholas Woods, Rebecca L Johnston, Juliet D French, Xiaoqing Chen, Maren Weischer, Sune F Nielsen, Melanie J Maranian, Maya Ghoussaini, Shahana Ahmed, Caroline Baynes, Manjeet K Bolla, Qin Wang, Joe Dennis, Lesley McGuffog, Daniel Barrowdale, Andrew Lee, Sue Healey, Michael Lush, Daniel C Tessier, Daniel Vincent, Françis Bacot, Australian Cancer Study, Australian Ovarian Cancer Study, Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Gene Environment Interaction and Breast Cancer (GENICA), Swedish Breast Cancer Study (SWE-BRCA), The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON), Epidemiological study of BRCA1 & BRCA2 Mutation Carriers (EMBRACE), Genetic Modifiers of Cancer Risk in BRCA1/2 Mutation Carriers (GEMO), Ignace Vergote, Sandrina Lambrechts, Evelyn Despierre, Harvey A Risch, Anna González-Neira, Mary Anne Rossing, Guillermo Pita, Jennifer A Doherty, Nuria Álvarez, Melissa C Larson, Brooke L Fridley, Nils Schoof, Jenny Chang-Claude, Mine S Cicek, Julian Peto, Kimberly R Kalli, Annegien Broeks, Sebastian M Armasu, Marjanka K Schmidt, Linde M Braaf, Boris Winterhoff, Heli Nevanlinna, Gottfried E Konecny, Diether Lambrechts, Lisa Rogmann, Pascal Guénel, Attila Teoman, Roger L Milne, Joaquin J Garcia, Angela Cox, Vijayalakshmi Shridhar, Barbara Burwinkel, Frederik Marme, Rebecca Hein, Elinor J Sawyer, Christopher A Haiman, Shan Wang-Gohrke, Irene L Andrulis, Kirsten B Moysich, John L Hopper, Kunle Odunsi, Annika Lindblom, Graham G Giles, Hermann Brenner, Jacques Simard, Galina Lurie, Peter A Fasching, Michael E Carney, Paolo Radice, Lynne R Wilkens, Anthony Swerdlow, Marc T Goodman, Hiltrud Brauch, Montserrat Garcia-Closas, Peter Hillemanns, Robert Winqvist, Matthias Dürst, Peter Devilee, Ingo Runnebaum, Anna Jakubowska, Jan Lubinski, Arto Mannermaa, Ralf Butzow, Natalia V Bogdanova, Thilo Dörk, Liisa M Pelttari, Wei Zheng, Arto Leminen, Hoda Anton-Culver, Clareann H Bunker, Vessela Kristensen, Roberta B Ness, Kenneth Muir, Robert Edwards, Alfons Meindl, Florian Heitz, Keitaro Matsuo, Andreas du Bois, Anna H Wu, Philipp Harter, Soo-Hwang Teo, Ira Schwaab, Xiao-Ou Shu, William Blot, Satoyo Hosono, Daehee Kang, Toru Nakanishi, Mikael Hartman, Yasushi Yatabe, Ute Hamann, Beth Y Karlan, Suleeporn Sangrajrang, Susanne Krüger Kjaer, Valerie Gaborieau, Allan Jensen, Diana Eccles, Estrid Høgdall, Chen-Yang Shen, Judith Brown, Yin Ling Woo, Mitul Shah, Mat Adenan Noor Azmi, Robert Luben, Siti Zawiah Omar, Kamila Czene, Robert A Vierkant, Børge G Nordestgaard, Henrik Flyger, Celine Vachon, Janet E Olson, Xianshu Wang, Douglas A Levine, Anja Rudolph, Rachel Palmieri Weber, Dieter Flesch-Janys, Edwin Iversen, Stefan Nickels, Joellen M Schildkraut, Isabel Dos Santos Silva, Daniel W Cramer, Lorna Gibson, Kathryn L Terry, Olivia Fletcher, Allison F Vitonis, C Ellen van der Schoot, Elizabeth M Poole, Frans B L Hogervorst, Shelley S Tworoger, Jianjun Liu, Elisa V Bandera, Jingmei Li, Sara H Olson, Keith Humphreys, Irene Orlow, Carl Blomqvist, Lorna Rodriguez-Rodriguez, Kristiina Aittomäki, Helga B Salvesen, Taru A Muranen, Elisabeth Wik, Barbara Brouwers, Camilla Krakstad, Els Wauters, Mari K Halle, Hans Wildiers, Lambertus A Kiemeney, Claire Mulot, Katja K Aben, Pierre Laurent-Puig, Anne Mvan Altena, Thérèse Truong, Leon F A G Massuger, Javier Benitez, Tanja Pejovic, Jose Ignacio Arias Perez, Maureen Hoatlin, M Pilar Zamora, Linda S Cook, Sabapathy P Balasubramanian, Linda E Kelemen, Andreas Schneeweiss, Nhu D Le, Christof Sohn, Angela Brooks-Wilson, Ian Tomlinson, Michael J Kerin, Nicola Miller, Cezary Cybulski, Brian E Henderson, Janusz Menkiszak, Fredrick Schumacher, Nicolas Wentzensen, Loic Le Marchand, Hannah P Yang, Anna Marie Mulligan, Gord Glendon, Svend Aage Engelholm, Julia A Knight, Claus K Høgdall, Carmel Apicella, Martin Gore, Helen Tsimiklis, Honglin Song, Melissa C Southey, Agnes Jager, Ans M Wvan den Ouweland, Robert Brown, John W M Martens, James M Flanagan, Mieke Kriege, James Paul, Sara Margolin, Nadeem Siddiqui, Gianluca Severi, Alice S Whittemore, Laura Baglietto, Valerie McGuire, Christa Stegmaier, Weiva Sieh, Heiko Müller, Volker Arndt, France Labrèche, Yu-Tang Gao, Mark S Goldberg, Gong Yang, Martine Dumont, John R McLaughlin, Arndt Hartmann, Arif B Ekici, Matthias W Beckmann, …, Roger R Reddel, Ellen L Goode, Mark H Greene, Douglas F Easton, Andrew Berchuck, Antonis C Antoniou, Georgia Chenevix-Trench & Alison M Dunning, 27 March 2013,自然遗传学.
DOI:10.1038/ng.2566

1注释科学家成功映射Telomerase发现各种癌症风险

  1. Madanagopal.V.C| 2013年4月1日10点41分| 回文

    优秀文章性细胞应该比普通细胞多倍数, 确实得到调聚器延展策略 以保持自身青春子宫癌和表白癌并发, 出自癌症细胞从游戏中获取的知识骨髓问题也是如此。 骨髓问题有很长的责任持续生产干细胞、多能细胞和红卡核单用调聚物延时策略并不容易理解 和全局复杂面向此方向的研究仅值寻找神粒子Higg's Boson和Darkmace

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